Understanding and Improving the Non-Human Primate Model for Human Immunodeficiency Virus Vaccine-Induced Mucosal Immunity

High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo

SB Lloyd, M Lichtfuss, TH Amarasena, S Alcantara, R De Rose, G Tachedjian, H Alinejad-Rokny, V Venturi, MP Davenport, WR Winnall, SJ Kent

2016-05-01

The low fidelity of HIV replication facilitates immune and drug escape. Some reverse transcriptase (RT) inhibitor drug-resistance ..

Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis

WR Winnall, SB Lloyd, R De Rose, S Alcantara, TH Amarasena, MP Hedger, JE Girling, SJ Kent

2015-03-01

The testis is a site of immune privilege in rodents, and there is evidence that T cell responses are also suppressed in the primat..

The high cost of fidelity

SB Lloyd, SJ Kent, WR Winnall

2014-01-01

The notoriously low fidelity of HIV-1 replication is largely responsible for the virus's rapid mutation rate, facilitating escape ..

The maturation of antibody technology for the HIV epidemic

WR Winnall, MD Beasley, RJ Center, MS Parsons, BR Kiefel, SJ Kent

2014-01-01

Antibodies are one of our most useful biological tools. Indeed, improvements in antibody-based technologies have ushered in a new ..

Characterisation of macaque testicular leucocyte populations and T-lymphocyte immunity

R De Rose, CS Fernandez, MP Hedger, SJ Kent, WR Winnall

2013-12-01

The rodent testis is well established as a site of immune privilege where both innate and acquired immune responses are suppressed..

Characterisation of simian immunodeficiency virus-infected cells in pigtail macaques

WR Winnall, A Sexton, S Alcantara, S Roath, R De Rose, SJ Kent

2012-06-20

Defining which cells become infected with simian immunodeficiency virus (SIV) in vivo should assist in unravelling the pathogenesi..